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DMP试剂在有机合成中的应用
发布日期:2012-02-09 09:47:02

Dess-Martin Periodinane (DMP)
CAS编码 87413-09-0
中文名 : 戴斯-马丁氧化剂
别名 : 1,1,1-Triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one


高碘试剂在有机合成化学中的应用,已经引起了广泛的关注,在众多高碘试剂中,12-I-53-乙酸基高碘酸盐(DMP试剂)以其温和的、选择性的反应特性,已经在多类有机合成反应中获得应用。同时,它还兼有低毒、易溶于多种溶剂及后处理简单等优点。DMP试剂作为常用的高碘试剂之一,之所以能温和的、选择性的参与众多的化学反应,主要得益于DMP试剂中元素I(Ⅴ)适中的氧化态,本文以DMP试剂参与不同类型的化学反应为划分依据,重点阐述DMP试剂参与的6种化学反应。


1 DMP试剂化学选择性氧化醇为相应的羰基化合物


   1.1 DMP试剂经一步反应氧化伯醇为醛,仲醇为酮


   1.2 DMP试剂参与的“氧化 WIttIg”同系化(一锅煮)反应


2 DMP试剂化学选择性氧化n 酰基羟基胺衍生物为酰基亚硝基化合物


3 肟经DMP试剂化学选择性氧化为相应的羰基化合物


4 DMP试剂化学选择性脱环状硫缩酮或硫缩醛保护基


5 DMP试剂化学选择性氧化醛为酰基叠氮化合物


6 DMP试剂区域选择性氧化芳香族衍生物


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